Clot Pathophysiology

Clot retraction facilitates clot lysis.

Platelet facilitation of clot lysis was studied using the dilute clot lysis assay, a standardized assay for fibrinolysis shown to correlate with the development of postoperative deep vein thrombosis. Clots prepared from dilute platelet poor plasma showed prolonged clot lysis when compared with clots prepared in a similar fashion from dilute platelet rich plasma. Since in the presence of platele...

Fibrin clot structure and function: a role in the pathophysiology of arterial and venous thromboembolic diseases.

The formation of fibrin clots that are relatively resistant to lysis represents the final step in blood coagulation. We discuss the genetic and environmental regulators of fibrin structure in relation to thrombotic disease. In addition, we discuss the implications of fibrin structure for treatment of thrombosis. Fibrin clots composed of compact, highly branched networks with thin fibers are res...

Clot firmness.

Clot control

For neurons, overexcitement is deadly. To avoid this, brain cells must sop up unneeded neurotransmitters from the synapse through membrane-bound transporters. If these transporters fail, neurons and other brain cells get excited to death—a phenomenon that may contribute to brain damage during stroke and Alzheimer's disease. Indeed, brain deterioration after stroke is associated with elevated le...

Feasibility of recording clot lysis with the thermometric clot detector.

Currently, the study of fibrinolysis is beset by problems of methodology (1 ). Disadvantages of many of the present methods for measurement of clot lysisincluding lysis time for the dilute blood clot, thromboelastography, euglobulin clot lysis, fibrin plate method, and caseinolytic assay (1 )-are imprecision of results and time required to perform the test (2). The electromechanical lysis timer...